Whoever had the brass to put the fictional versions of Harlan Ellison, Majel Barrett Roddenberry and Jeri Ryan on the same panel must be the sort of person who likes Chris Matthews' Hardball.
I've told the Harlan story many, many times already, so I'll save it for later in these annotations. Suffice it to say he was a friend of the strip. Likewise, I'll refrain from describing Jeni McRian too much except to say she has a bit of Jenny McCarthy in her too.
The signs at the bottom aren't meant to make complete sense, but "crackbrained moron blowing bullshit" wouldn't be a bad translation.